Publications

2021
Yelena Losev, Moran Frenkel-Pinter, Malak Abu-Hussien, Guru Krishnakumar Viswanathan, Donna Elyashiv-Revivo, Rana Geries, Isam Khalaila, Ehud Gazit, and Daniel Segal. 2021. “Differential effects of putative N-glycosylation sites in human Tau on Alzheimer’s disease-related neurodegeneration.” Cellular and Molecular Life Sciences, 78, 5, Pp. 2231-2245.
Moran Frenkel-Pinter, Alyssa B Sargon, Jennifer B Glass, Nicholas V Hud, and Loren Dean Williams. 2021. “Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine.” RSC Advances, 11, 6, Pp. 3534-3538.
Moran Frenkel-Pinter, Vahab Rajaei, Jennifer B Glass, Nicholas V Hud, and Loren Dean Williams. 2021. “Water and life: The medium is the message.” Journal of molecular evolution, 89, 1, Pp. 2-11.
2020
Rebecca Guth-Metzler, Marcus S Bray, Moran Frenkel-Pinter, Suttipong Suttapitugsakul, Claudia Montllor-Albalate, Jessica C Bowman, Ronghu Wu, Amit R Reddi, Denise C Okafor, and Jennifer B Glass. 2020. “Cutting in-line with iron: ribosomal function and non-oxidative RNA cleavage.” Nucleic acids research, 48, 15, Pp. 8663-8674.
Moran Frenkel-Pinter, Jay W Haynes, Ahmad M Mohyeldin, C Martin, Alyssa B Sargon, Anton S Petrov, Ramanarayanan Krishnamurthy, Nicholas V Hud, Loren Dean Williams, and Luke J Leman. 2020. “Mutually stabilizing interactions between proto-peptides and RNA.” Nature communications, 11, 1, Pp. 1-14.
Yi Sun, Moran Frenkel-Pinter, Charles L Liotta, and Martha A Grover. 2020. “The pH dependent mechanisms of non-enzymatic peptide bond cleavage reactions.” Physical Chemistry Chemical Physics, 22, 1, Pp. 107-113.
Moran Frenkel-Pinter, Mousumi Samanta, Gonen Ashkenasy, and Luke J Leman. 2020. “Prebiotic peptides: Molecular hubs in the origin of life.” Chemical reviews, 120, 11, Pp. 4707-4765.
Jessica C Bowman, Anton S Petrov, Moran Frenkel-Pinter, Petar I Penev, and Loren Dean Williams. 2020. “Root of the tree: the significance, evolution, and origins of the ribosome.” Chemical reviews, 120, 11, Pp. 4848-4878.
Ashim Paul, Moran Frenkel-Pinter, Daniela Escobar Alvarez, Giulia Milordini, Ehud Gazit, Elsa Zacco, and Daniel Segal. 2020. “Tryptophan-galactosylamine conjugates inhibit and disaggregate amyloid fibrils of Aβ42 and hIAPP peptides while reducing their toxicity.” Communications biology, 3, 1, Pp. 1-12.
2019
Yelena Losev, Ashim Paul, Moran Frenkel-Pinter, Malak Abu-Hussein, Isam Khalaila, Ehud Gazit, and Daniel Segal. 2019. “Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity.” Scientific reports, 9, 1, Pp. 1-10.
Moran Frenkel-Pinter, Jay W Haynes, C Martin, Anton S Petrov, Bradley T Burcar, Ramanarayanan Krishnamurthy, Nicholas V Hud, Luke J Leman, and Loren Dean Williams. 2019. “Selective incorporation of proteinaceous over nonproteinaceous cationic amino acids in model prebiotic oligomerization reactions.” Proceedings of the National Academy of Sciences, 116, 33, Pp. 16338-16346.
2018
Moran Frenkel‐Pinter, Michal Richman, Anna Belostozky, Amjaad Abu‐Mokh, Ehud Gazit, Shai Rahimipour, and Daniel Segal. 2018. “Distinct Effects of O‐GlcNAcylation and Phosphorylation of a Tau‐Derived Amyloid Peptide on Aggregation of the Native Peptide.” Chemistry–A European Journal, 24, 53, Pp. 14039-14043.
2017
Moran Frenkel-Pinter, Shiri Stempler, Sharon Tal-Mazaki, Yelena Losev, Avnika Singh-Anand, Daniela Escobar-Alvarez, Jonathan Lezmy, Ehud Gazit, Eytan Ruppin, and Daniel Segal. 2017. “Altered protein glycosylation predicts Alzheimer's disease and modulates its pathology in disease model Drosophila.” Neurobiology of aging, 56, Pp. 159-171.
Moran Frenkel-Pinter, Sharon Tal, Roni Scherzer-Attali, Malak Abu-Hussien, Idan Alyagor, Tal Eisenbaum, Ehud Gazit, and Daniel Segal. 2017. “Cl-NQTrp alleviates tauopathy symptoms in a model organism through the inhibition of tau aggregation-engendered toxicity.” Neurodegenerative Diseases, 17, 2-3, Pp. 73-82.
Marina Chemerovski‐Glikman, Moran Frenkel‐Pinter, Ragad Mdah, Amjaad Abu‐Mokh, Ehud Gazit, and Daniel Segal. 2017. “Inhibition of the aggregation and toxicity of the minimal amyloidogenic fragment of tau by its pro‐substituted analogues.” Chemistry–A European Journal, 23, 40, Pp. 9618-9624.
Moran Frenkel-Pinter, Merav Daniel Shmueli, Chen Raz, Michaela Yanku, Shai Zilberzwige, Ehud Gazit, and Daniel Segal. 2017. “Interplay between protein glycosylation pathways in Alzheimer’s disease.” Science advances, 3, 9, Pp. e1601576.
2016
Moran Frenkel-Pinter, Chen Raz, Ehud Gazit, and Daniel Segal. 2016. “Boiling reduces glycan detection of glycoproteins.” CIBTech Journal of Bio-Protocols, 5, 1, Pp. 4-8.
Moran Frenkel-Pinter, Sharon Tal, Roni Scherzer-Attali, Malak Abu-Hussien, Idan Alyagor, Tal Eisenbaum, Ehud Gazit, and Daniel Segal. 2016. “Naphthoquinone-tryptophan hybrid inhibits aggregation of the tau-derived peptide PHF6 and reduces neurotoxicity.” Journal of Alzheimer's Disease, 51, 1, Pp. 165-178.
Moran Frenkel‐Pinter, Michal Richman, Anna Belostozky, Amjaad Abu‐Mokh, Ehud Gazit, Shai Rahimipour, and Daniel Segal. 2016. “Selective inhibition of aggregation and toxicity of a Tau‐derived peptide using its glycosylated analogues.” Chemistry–A European Journal, 22, 17, Pp. 5945-5952.
2013
Ronit Shaltiel-Karyo, Moran Frenkel-Pinter, Edward Rockenstein, Christina Patrick, Michal Levy-Sakin, Abigail Schiller, Nirit Egoz-Matia, Eliezer Masliah, Daniel Segal, and Ehud Gazit. 2013. “A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD).” Journal of Biological Chemistry, 288, 24, Pp. 17579-17588.